background:  new discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. we aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. based on the general faster progression rate of wrist osteoarthritis, we hypothes...

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Inflammatory cytokines play critical roles in the pathogenesis of osteoarthritis. Recent studies have demonstrated that natural active substances can serve as alternative therapeutic agents for the prevention and treatment of osteoarthritis. Sanguinarine, an alkaloid isolated from the roots of Sanguinaria canadensis, is known to have anti-inflammatory properties. The aim of the present study wa...

BACKGROUND MMP-13 is one of the most important metalloproteases (MMP) involved in osteoarthritis. Licofelone, a novel dual inhibitor of cyclo-oxygenases (COX) and 5-lipoxygenase (5-LOX), can modulate MMP-13 production in human osteoarthritis chondrocytes. OBJECTIVE To evaluate the impact of licofelone on MMP-13 expression/production, promoter, and major MAP kinase signalling pathways and tran...

BACKGROUND This is a systematic review of studies on the prevalence of osteoarthritis in the tibiofemoral joint more than 10 years after an anterior cruciate ligament injury, the radiologic classification methods used, and risk factors for development of knee osteoarthritis. METHODS A systematic search was performed in PubMed, EMBASE, and AMED. Inclusion criteria were studies involving patien...

OBJECTIVE To determine the dimensionality, reliability, model fit, adequacy of the qualifier levels, response patterns across different factors, and targeting of the International Classification of Functioning, Disability and Health (ICF) osteoarthritis core set categories in people with osteoarthritis undergoing hip and knee arthroplasty. METHODS The osteoarthritis core set was rated in 316 ...

iv CHAPTER 1: GENERAL INTRODUCTION INTRODUCTION 1 CHAPTER 2: REVIEW OF LITERATURE 1.1 Incidence and Prevalence of Knee Osteoarthritis following ACL Rupture 5 1.2 Functional Anatomy 1.2.1 The ACL 7 1.2.2 Articular Cartilage 9 1.3 Injury to the ACL 10 1.4 Gait Analysis 12 1.5 Neuromuscular Adaptations following ACL injury leading to Knee Osteoarthritis 1.5.1 Quadriceps Weakness 13 1.5.2 Frontal P...

OBJECTIVES Despite the rising number of patients with osteoarthritis, no sufficient chondroprotective and prophylactic therapy for osteoarthritis has been established yet. The purpose of this study was to verify whether stimulation of the nicotinic acetylcholine receptor via nicotine has a beneficial effect on cartilage degeneration in the development of osteoarthritis and is capable of reducin...

Introduction Osteoarthritis (OA) is the most common form of degenerative joint disease characterized by progressive degeneration articular cartilage, osteophyte formation, and space narrowing. Matrix metalloproteinases (MMPs) are potential biomarkers for osteoarthritis. Aims objective The study's aim estimation serum synovial fluid matrix metalloproteinase (MMP) 13 vitamin D levels in grade 3 4...